N-ACETYL SELANK AMIDATE 10mg

Description

⚠ For laboratory research use only. Not for human consumption.

CAS NO: 129954-34-3

Molecular Formula: C33H57N11O9

Molecular Weight: 751.9 g/mol

Form: Lyophilized powder

Appearance: white powder

Storage: 2-8°C

Purity: ≥99%

N-Acetyl Selank Amidate (NA Selank) is a modified version of the peptide Selank, a synthetic analog of the naturally occurring peptide tuftsin. The modifications—N-terminal acetylation and C-terminal amidation—are designed to make the peptide more resistant to breakdown and potentially increase its stability and duration of action.

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KEY RESEARCH APPLICATIONS:

• Anxiolytic-like activity studies without sedative effects
• Cognitive enhancement and memory retention research
• Neurotransmitter modulation (serotonin, dopamine, norepinephrine)
• Neuroinflammatory and cytokine regulation
• Immunotropic mechanism investigations

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PRIMARY RESEARCH APPLICATIONS

 

1. ANXIOLYTIC-LIKE ACTIVITY WITHOUT SEDATION

Unlike classical benzodiazepines, N-Acetyle Selank Amidate does not appear to produce muscle relaxation, motor coordination deficits, or amnestic effects in preclinical models. Researchers have observed dose-dependent reductions in elevated plus-maze and open field test anxiety indicators, suggesting potential modulation of the GABAergic system—though via a distinct, non-benzodiazepine pathway.

 

2. COGNITIVE ENHANCEMENT & NOOTROPIC POTENTIAL

Studies have reported improvements in learning acquisition and memory retention in rodent models of scopolamine-induced amnesia and stress-impaired cognition. N-Acetyle Selank Amidate  appears to influence brain-derived neurotrophic factor (BDNF) expression and may support hippocampal neurogenesis under stress conditions.

 

3. NEUROINFLAMMATORY MODULATION

N-Acetyle Selank Amidate exhibits immunotropic properties linked to its tuftsin backbone. Research indicates it may downregulate pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and upregulate anti-inflammatory IL-10 in central nervous system tissues. This has drawn interest in models of chronic stress, traumatic brain injury, and neuropathic pain.

 

4. NEUROTRANSMITTER REGULATION

Investigations using microdialysis and tissue homogenates have demonstrated that N-Acetyle Selank Amidate  may alter extracellular levels of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in the prefrontal cortex and hippocampus. These changes are region-specific and dose-dependent, offering a research avenue for understanding its mechanism of action.

 

5. VIRAL & IMMUNE RESEARCH (IN VITRO)

Due to its tuftsin homology, N-Acetyle Selank Amidate has been evaluated for its ability to modulate interferon-gamma (IFN-γ) and other antiviral signaling molecules in cultured immune cells. This application remains exploratory but is documented in peer-reviewed immunology literature.

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EXPERIMENTAL PREPARATION

For accurate research application:

1. Reconstitutewith appropriate volume of bacteriostatic water
2. Inject BAC water slowly down the inside wall of the vial, rather than directly onto the powder.
3. Gently swirluntil fully dissolved (do not vortex)
4. Administerimmediately or store at 4°C protected from light
5. Reconstituted: Stable 30 days at 4°C

 

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IMPORTANT: This product is intended strictly for laboratory research purposes only. NOT for human or animal consumption. NOT for medical or diagnostic use. These products have not undergone evaluation by the U.S. Food and Drug Administration. By purchasing, you confirm compliance with all applicable regulations.