MOTSc 10MG

Description

⚠ For laboratory research use only. Not for human consumption.

CAS NO: 1627580-64-6

Molecular Formula: C101H152N28O22S2.C2HF3O2

Molecular Weight: 2288.6 g/mol

Form: Lyophilized powder

Appearance: white powder

Storage: 2-8°C

Purity: ≥99%

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MOTS-C PEPTIDE – MITOCHONDRIAL-DERIVED PEPTIDE FOR METABOLIC, ANTI-AGING & PERFORMANCE RESEARCH

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide that has emerged as one of the most exciting breakthroughs in metabolic, anti-aging, and exercise performance research. Encoded within the mitochondrial genome, MOTS-c regulates nuclear gene expression, glucose metabolism, and insulin sensitivity and cellular longevity making it a powerful tool for studying age-related metabolic decline, obesity, and mitochondrial dysfunction.

Ideal for studying:

Metabolic disorders (diabetes/obesity models)

Anti-aging & lifespan extension

Exercise performance & muscle recovery

Neuroprotection & cognitive function

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KEY RESEARCH APPLICATIONS OF MOTS-C

 

1. METABOLIC REGULATION & INSULIN SENSITIVITY

MOTS has been shown to enhance glucose uptake and improve insulin sensitivity, making it a valuable peptide for studying:

• Type 2 diabetes models
• Obesity-related metabolic dysfunction
• Insulin resistance mechanisms

 

Mechanism of Action:

• Activates AMPK pathway– Enhances cellular energy sensing and glucose metabolism (Lee et al., 2015).
• Upregulates GLUT4 translocation– Improves glucose uptake in skeletal muscle (Reynolds et al., 2021).
• Modulates mitochondrial biogenesis– Supports efficient ATP production (Kumagai et al., 2020).

 

2. ANTI-AGING & LONGEVITY RESEARCH

 

MOTS has demonstrated potent anti-aging effects by:

• Reducing oxidative stress– Protects against mitochondrial DNA damage (Kim et al., 2018).
• Enhancing cellular stress resistance– Upregulates antioxidant pathways (Zempo et al., 2022).
• Promoting lifespan extension– Observed in  elegans and murine models (Wan et al., 2020).

 

3. EXERCISE PERFORMANCE & MUSCLE ENDURANCE

MOTS has been studied for its ergogenic potential, including:

• Enhancing exercise capacity– Improves endurance in animal models (Qin et al., 2018).
• Reducing muscle fatigue– Supports ATP regeneration (Yamamoto et al., 2021).
• Promoting muscle recovery– Accelerates repair post-exercise (Mendelsohn et al., 2022).

 

4. NEUROPROTECTION & COGNITIVE FUNCTION

Emerging research suggests MOTS may:

• Protect against neurodegeneration– Reduces amyloid-beta toxicity (Cohen et al., 2022).
• Enhance cognitive function– Improves memory retention in aging models (Lu et al., 2023).
• Modulate neuroinflammation– Suppresses microglial activation (Zhang et al., 2021).

 

Supporting Studies:

Cohen et al. (2022) – “MOTS-c reduces amyloid-beta accumulation in Alzheimer’s models.”

 

Lu et al. (2023) – “MOTS-c improves hippocampal-dependent memory in aged mice.”

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EXPERIMENTAL PREPARATION

For accurate research application:

1. Reconstitutewith appropriate volume of bacteriostatic water
2. Inject BAC water slowly down the inside wall of the vial, rather than directly onto the powder.
3. Gently swirluntil fully dissolved (do not vortex)
4. Administerimmediately or store at 4°C protected from light
5. Reconstituted: Stable 30 days at 4°C

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IMPORTANT: This product is intended strictly for laboratory research purposes only. NOT for human or animal consumption. NOT for medical or diagnostic use. These products have not undergone evaluation by the U.S. Food and Drug Administration. By purchasing, you confirm compliance with all applicable regulations.