CJC 1295 NO DAC

Description

⚠ For laboratory research use only. Not for human consumption.

CAS NO: 863288-34-0

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.9 g/mol

Form: Lyophilized powder

Appearance: white powder

Storage: 2-8°

Purity: ≥99

CJC-1295 No DAC 5mg (Modified GRF 1-29) – A Growth Hormone-Releasing Peptide for Endocrine and Metabolic Research, Intended for laboratory use only by qualified researchers. This product is strictly not for human or veterinary consumption.

Primary Research Applications:

• Pituitary Somatotroph Function & GH Secretion Studies
• GHRH Receptor Signaling & cAMP Pathway Analysis
• Comparative Research with DAC-Containing Analogs
• Pulsatile GH Release & Metabolic Modeling

A PRECISE TOOL FOR PULSATILE GH RESEARCH: A GUIDE TO CJC-1295 NO DAC

Welcome, esteemed researchers, to Elite Wellness Peptide’s detailed examination of a refined growth hormone-releasing peptide: CJC-1295 No DAC (also known as Modified GRF 1-29 or Tetrasubstituted GRF). This product contains 5mg of high-purity, lyophilized peptide, representing a precise tool for investigating the dynamics of the hypothalamic-pituitary axis. CJC-1295 No DAC is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH), modified for enhanced stability and receptor binding, while specifically lacking the Drug Affinity Complex (DAC) moiety that confers extended duration of action. This deliberate design allows researchers to study pulsatile growth hormone (GH) release patterns without the sustained elevation associated with the DAC version. This product description serves as a foundational research primer to guide your experimental design in endocrinology, metabolism, and cellular signaling.

SECTION 1: THE SCIENTIFIC BASIS OF CJC-1295 NO DAC’S MECHANISM OF ACTION

The research value of CJC-1295 No DAC lies in its targeted interaction with the growth hormone-releasing hormone receptor (GHRH-R) and its ability to stimulate natural, pulsatile GH secretion patterns.

1. Targeted GHRH Receptor Agonism:CJC-1295 No DAC is a potent, synthetic agonist of the GHRH receptor, which is primarily expressed on somatotroph cells in the anterior pituitary gland. Upon binding to this G-protein-coupled receptor, it initiates a signaling cascade involving cyclic AMP (cAMP) and protein kinase A (PKA), leading to the synthesis and secretion of growth hormone (GH) from storage vesicles.
2. Enhanced Stability Through Structural Modification:The peptide is a tetra-substituted analog of the endogenous GHRH (1-29) sequence. It incorporates modifications (specifically, substituting the first two amino acids with D-Ala and modifying positions 8, 15, and 27) that confer resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4). This results in a significantly extended half-life in experimental models compared to native GHRH (1-29), allowing for more sustained receptor activation in research settings.
3. Absence of DAC for Natural Pulsatility:Unlike its counterpart CJC-1295 with DAC, the “No DAC” version lacks the Drug Affinity Complex. The DAC moiety is designed to covalently bind to serum albumin, creating a depot effect and prolonging the molecule’s circulation time to over a week. By omitting this, CJC-1295 No DAC maintains a shorter, more physiological-like half-life, enabling researchers to study the effects of discrete, pulsatile GH stimulation—a critical feature of normal GH physiology—rather than continuous GH elevation.

EXPERIMENTAL PREPARATION

For accurate research application:

1. Reconstitutewith appropriate volume of bacteriostatic water
2. Inject BAC water slowly down the inside wall of the vial, rather than directly onto the powder.
3. Gently swirluntil fully dissolved (do not vortex)
4. Administerimmediately or store at 4°C protected from light
5. Reconstituted: Stable 30 days at 4°C

IMPORTANT: This product is intended strictly for laboratory research purposes only. NOT for human or animal consumption. NOT for medical or diagnostic use. These products have not undergone evaluation by the U.S. Food and Drug Administration. By purchasing, you confirm compliance with all applicable regulations.