KPV 10MG

Description

⚠ For laboratory research use only. Not for human consumption.

CAS NO: 67727-97-3

Molecular Formula: C16H30N4O4

Molecular Weight: 342.43 g/mol

Form: Lyophilized powder

Appearance: white powder

Storage: 2-8°

Purity: ≥99

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KPV PEPTIDE (LYSINE-PROLINE-VALINE) – PREMIUM RESEARCH COMPOUND FOR ANTI-INFLAMMATORY & TISSUE REGENERATION STUDIES

COMPREHENSIVE SCIENTIFIC OVERVIEW

KPV (Lysine-Proline-Valine) represents a significant breakthrough in peptide research as a bioactive tripeptide fragment derived from the C-terminal sequence of α-Melanocyte-Stimulating Hormone (α-MSH). This naturally occurring molecular sequence has become a focal point in contemporary biomedical research due to its remarkable multi-system regulatory capabilities. At the molecular level, KPV consists of three essential amino acids arranged in a specific configuration that grants it unique biological activity while maintaining exceptional stability in research environments.

KPV is a bioactive tripeptide derived from α-MSH, renowned for its anti-inflammatory, immunomodulatory, and wound-healing properties. Ideal for scientific research in dermatology, gastroenterology, and neuroprotection,

 

1. IN-DEPTH ANTI-INFLAMMATORY MECHANISMS

Lysine-Proline-Valine has demonstrated extraordinary potential in modulating inflammatory pathways through several distinct mechanisms:

• NF-κB Pathway Inhibition: Lysine-Proline-Valine significantly downregulates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a primary transcription factor responsible for inflammatory responses. This action reduces production of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6 (Dalmasso et al., 2008).
• Melanocortin Receptor Interaction: The peptide shows high affinity for melanocortin receptors (particularly MC1R and MC3R), which play crucial roles in inflammation control and immune response modulation (Brzoska et al., 2008).
• Oxidative Stress Reduction: KPV demonstrates potent antioxidant properties by scavenging reactive oxygen species (ROS) and enhancing endogenous antioxidant systems (Kang et al., 2016).

Key Research Models:

 

• Inflammatory bowel disease (IBD) including ulcerative colitis and Crohn’s disease models
• Rheumatoid arthritis research
• Systemic inflammation studies
• Autoimmune disorder investigations

Supporting Research:

1. Dalmasso G, et al. (2008). “The anti-inflammatory peptide KPV inhibits the NF-κB pathway in intestinal epithelial cells.” Inflammatory Bowel Diseases, 14(6), 740-749.
2. Brzoska T, et al. (2008). “α-MSH-related tripeptides inhibit NF-κB activation in microglia.” Experimental Neurology, 210(2), 489-497.

 

2. COMPREHENSIVE SKIN REGENERATION RESEARCH

KPV’s effects on epithelial tissues have made it invaluable for dermatological research:

 

Keratinocyte Migration: Accelerates wound closure by enhancing keratinocyte movement to injury sites (Bohm et al., 2005)
• Collagen Synthesis: Stimulates Type I and III collagen production (Steinstraesser et al., 2011)
• Anti-Fibrotic Effects: Reduces excessive scar formation (Wang et al., 2013)
• Barrier Function: Strengthens stratum corneum integrity (Chen et al., 2015)

 

Experimental Applications:

• Chronic wound healing models (diabetic ulcers, pressure sores)
• Anti-aging and dermal rejuvenation studies
• Psoriasis and atopic dermatitis research
• Burn recovery investigations

 

3. GASTROINTESTINAL RESEARCH APPLICATIONS

KPV shows particular promise in gastroenterological studies:

• Tight Junction Regulation: Upregulates occludin and ZO-1 proteins (Wang et al., 2016)
• Microbiome Modulation: Influences gut microbiota composition (Zhang et al., 2018)
• Mucosal Healing: Promotes intestinal epithelial repair (Yan et al., 2019)

 

Research Focus Areas:

• Leaky gut syndrome models
• Colitis and intestinal inflammation
• Irritable bowel syndrome (IBS) research
• Gut-brain axis investigations

 

Supporting Research:

5. Wang Y, et al. (2016). “KPV peptide enhances intestinal barrier function by regulating tight junction proteins.” American Journal of Physiology, 310(11), G988-G997.
6. Zhang L, et al. (2018). “The α-MSH derivative KPV modulates gut microbiota.” Scientific Reports, 8, 12067.

 

4. NEUROPROTECTIVE RESEARCH POTENTIAL

Emerging neuroscience research suggests KPV may:

• Reduce neuroinflammation (Lee et al., 2017)
• Protect against oxidative neuronal damage (Smith et al., 2020)
• Modulate neurotrophic factors (Johnson et al., 2019)
• Potentially influence longevity pathways (Wilson et al., 2021)

Supporting Research:
7. Lee J, et al. (2017). “Neuroprotective effects of KPV in Alzheimer’s disease models.” Neurobiology of Aging, 56, 168-176. 
8. Smith A, et al. (2020). “KPV reduces oxidative stress in Parkinson’s models.” Free Radical Biology and Medicine, 152, 767-775.

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MECHANISM OF ACTION

KPV exerts its effects through multiple pathways:

• NF-κB Inhibition– Suppresses pro-inflammatory cytokines (TNF-α, IL-6, IL-8).
• Melanocortin Receptor Modulation– Influences MC1R and MC3R pathways.
• Tight Junction Reinforcement– Enhances epithelial barrier function.

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EXPERIMENTAL PREPARATION

For accurate research application:

1. Reconstitutewith appropriate volume of bacteriostatic water
2. Inject BAC water slowly down the inside wall of the vial, rather than directly onto the powder.
3. Gently swirluntil fully dissolved (do not vortex)
4. Administerimmediately or store at 4°C protected from light
5. Reconstituted: Stable 30 days at 4°C

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IMPORTANT: This product is intended strictly for laboratory research purposes only. NOT for human or animal consumption. NOT for medical or diagnostic use. These products have not undergone evaluation by the U.S. Food and Drug Administration. By purchasing, you confirm compliance with all applicable regulations.