THYMOSIN ALPHA 1 10MG

Description

⚠ For laboratory research use only. Not for human consumption.

CAS NO: 62304-98-7

Molecular Formula: C129H215N33O55

Molecular Weight: 3108.32 g/mol

Form: Lyophilized powder

Appearance: white powder

Storage: 2-8°

Purity: ≥99%

Thymosin Alpha-1 (TA1) is a naturally occurring peptide made up of 28 amino acids. It is produced by the thymus gland and plays an important role in the development and regulation of the immune system. It is one of the most researched immune-modulating peptides available.

What researchers study TA1 for

• Immune system regulation
• T-cell function and maturation
• Viral infections
• Chronic inflammation
• Immune recovery
• Healthy aging and immune resilience

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How it works

TA1 helps regulate and support the immune response by:

• Promoting T-cell development and activity
• Enhancing natural killer (NK) cell function
• Supporting dendritic cell activity
• Helping coordinate innate and adaptive immunity

Unlike many peptides that are focused on growth hormone release or tissue repair, TA1 is primarily studied for its effects on immune function.

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Potential benefits reported in research

Researchers have investigated TA1 for:

• Supporting immune function during infections
• Improving vaccine responses
• Immune recovery in immunocompromised individuals
• Reducing excessive inflammatory responses
• Supporting overall immune resilience

 

Research and clinical status

TA1 has been studied extensively worldwide and is approved in some countries for certain immune-related conditions. During the COVID-19 pandemic, it was also investigated as a potential immune-supportive therapy in hospitalized patients.

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RESEARCH FOCUS: THE MULTIFACETED ROLE OF THYMOSIN ALPHA-1 IN IMMUNOLOGY AND BEYOND

Thymosin Alpha-1 represents a cornerstone of modern immunomodulation research with demonstrated effects across multiple physiological systems. Its research applications span several critical areas of modern biomedical science:

• Immunomodulation & Immune System Reconstitution:Investigating mechanisms of T-cell differentiation, maturation, and cytokine production in models of immune deficiency.
• Anti-Aging & Immunosenescence:Researching the peptide’s potential to reverse or mitigate the age-related decline in immune function and increase resistance to infection.
• Oncological Research & Adjunct Therapy:Studying its role in enhancing anti-tumor immune responses and potentially improving outcomes in combination with other therapies.
• Anti-Inflammatory & Anti-Septic Actions:Exploring its powerful effects in modulating cytokine storms and improving survival in models of severe sepsis and systemic inflammation.
• Viral Immunology:Examining its potential to enhance vaccine response and modulate immune activity during chronic viral infections.

 

1. THYMOSIN ALPHA-1 AS AN IMMUNOMODULATOR AND T-CELL ACTIVATOR

Mechanism of Action:
Thymosin Alpha-1 exerts its primary effects through sophisticated modulation of the immune system, with a particular focus on T-lymphocytes:

 

• T-Cell Maturation & Differentiation:Promotes the maturation of T-cell precursors in the thymus and enhances the differentiation of CD4+ helper T-cells and CD8+ cytotoxic T-cells, which are essential for adaptive immunity.
• Cytokine Regulation:Modulates the production of key cytokines, including increasing interferon-gamma (IFN-γ), interleukin-2 (IL-2), and interleukin-12 (IL-12) while decreasing pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1).
• Enhancement of Dendritic Cell Function:Improves the antigen-presenting capacity of dendritic cells, bridging the innate and adaptive immune responses.
• Stimulation of Natural Killer (NK) Cell Activity:Increases the cytotoxicity of NK cells, enhancing the innate immune system’s ability to target infected or malignant cells.

 

Research Applications & Key Studies:

• Immune Reconstitution in Immunodeficiency Models:Studies have shown TA-1’s efficacy in restoring immune function in models of chemotherapy-induced immunosuppression or age-related immunosenescence.

 

2. THYMOSIN ALPHA-1 IN ANTI-AGING AND IMMUNOSENESCENCE RESEARCH

Mechanism of Action:
Aging is characterized by a progressive decline in immune competence, known as immunosenescence. TA-1 is a leading compound for research in this field:

 

• Reversal of Thymic Atrophy:The thymus gland atrophies with age, drastically reducing T-cell output. TA-1 has been shown to promote thymic regeneration and increase thymic mass and cellularity in aged animal models.
• Restoration of Naive T-Cell Pools:Helps replenish the pool of naïve T-cells, which is essential for responding to new pathogens.
• Reduction of Inflammatory Aging (“Inflammaging”):Counteracts the chronic, low-grade inflammation associated with aging by modulating pro-inflammatory cytokine production.
• Enhancement of Immune Surveillance:Improves the ability of the aged immune system to identify and eliminate precancerous and senescent cells.

 

Research Applications & Key Studies:

• Reversal of Age-Related Immune Decline:Studies in aged mice have demonstrated that TA-1 treatment can restore youthful immune parameters, including T-cell proliferation and cytokine production.

 

3. THYMOSIN ALPHA 1 IN ONCOLOGICAL AND ADJUNCT THERAPY RESEARCH

Mechanism of Action:
TA-1’s role in cancer research focuses on boosting the host’s anti-tumor immunity rather than direct cytotoxicity:

 

• Enhancement of Tumor-Infiltrating Lymphocytes (TILs):Promotes the migration and activity of T-cells within the tumor microenvironment.
• Attenuation of Myeloid-Derived Suppressor Cells (MDSCs):Can reduce the population of these immune-suppressive cells that are prevalent in many cancers.
• Synergy with Checkpoint Inhibitors:Preclinical data suggests it may enhance the efficacy of PD-1/PD-L1 blockade therapies by creating a more immunogenic tumor microenvironment.
• Reduction of Chemotherapy-Induced Immunosuppression:Helps protect the immune system from the damaging effects of cytotoxic cancer therapies.

 

Research Applications & Key Studies:

• Adjunct to Cancer Immunotherapy:Studies in murine tumor models (e.g., melanoma, lung carcinoma) have shown that TA-1 can slow tumor growth and improve survival when combined with other therapies.

 

Best for: Investigating combination cancer immunotherapies, modulating the tumor microenvironment, and studying host-tumor immune interactions.

 

4. THYMOSIN ALPHA-1 IN SEPSIS AND SEVERE INFLAMMATION RESEARCH

Mechanism of Action:
In hyperinflammatory conditions like sepsis, TA-1 appears to restore immune balance rather than broadly suppress inflammation:

 

• Modulation of Cytokine Storm:Selectively dampens excessive production of pro-inflammatory cytokines (TNF-α, IL-6) while preserving or enhancing anti-inflammatory and regulatory pathways.
• Improvement of Immune Cell Function:Prevents the apoptosis (programmed cell death) of lymphocytes that is characteristic of sepsis, helping to maintain immune competence.
• Protection Against Endotoxin:Increases survival in models of endotoxic shock.

 

Best for: Research on sepsis pathophysiology, cytokine storm modulation, acute respiratory distress syndrome (ARDS), and immune dysregulation in critical illness

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EXPERIMENTAL PREPARATION

For accurate research application:

1. Reconstitutewith appropriate volume of bacteriostatic water
2. Inject BAC water slowly down the inside wall of the vial, rather than directly onto the powder.
3. Gently swirluntil fully dissolved (do not vortex)
4. Administerimmediately or store at 4°C protected from light
5. Reconstituted: Stable 30 days at 4°C

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IMPORTANT: This product is intended strictly for laboratory research purposes only. NOT for human or animal consumption. NOT for medical or diagnostic use. These products have not undergone evaluation by the U.S. Food and Drug Administration. By purchasing, you confirm compliance with all applicable regulations.