N- ACETYLE SELANK/SEMAX AMITE 10/10MG

Description

⚠ For laboratory research use only. Not for human consumption.

This product is a blend of N- Acetyle SELANK  Amidate 10MG and N- Acetyle SEMAX Amidate 10MG

Appearance: White powder
Form: Lyophilized powder
Storage: 2-8°
Purity: ≥99

N-Acetyle Selank Amidate

CAS NO: 129954-34-3

Molecular Formula: C33H57N11O9

Molecular Weight: 751.9 g/mol

N- Acetyle Semax Amidate

CAS NO: 2920938-90-3

Molecular Formula: C39H54N10O10S

Molecular Weight: 854.97 g/mol

N-Acetyl Selank Amidate (NA Selank) is a modified version of the peptide Selank, a synthetic analog of the naturally occurring peptide tuftsin. The modifications—N-terminal acetylation and C-terminal amidation—are designed to make the peptide more resistant to breakdown and potentially increase its stability and duration of action.

KEY RESEARCH APPLICATIONS:

• Anxiolytic-like activity studies without sedative effects
• Cognitive enhancement and memory retention research
• Neurotransmitter modulation (serotonin, dopamine, norepinephrine)
• Neuroinflammatory and cytokine regulation
• Immunotropic mechanism investigations

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PRIMARY RESEARCH APPLICATIONS

 

1. ANXIOLYTIC-LIKE ACTIVITY WITHOUT SEDATION

Unlike classical benzodiazepines, N-Acetyle Selank Amidate does not appear to produce muscle relaxation, motor coordination deficits, or amnestic effects in preclinical models. Researchers have observed dose-dependent reductions in elevated plus-maze and open field test anxiety indicators, suggesting potential modulation of the GABAergic system—though via a distinct, non-benzodiazepine pathway.

 

2. COGNITIVE ENHANCEMENT & NOOTROPIC POTENTIAL

Studies have reported improvements in learning acquisition and memory retention in rodent models of scopolamine-induced amnesia and stress-impaired cognition. N-Acetyle Selank Amidate  appears to influence brain-derived neurotrophic factor (BDNF) expression and may support hippocampal neurogenesis under stress conditions.

 

3. NEUROINFLAMMATORY MODULATION

N-Acetyle Selank Amidate exhibits immunotropic properties linked to its tuftsin backbone. Research indicates it may downregulate pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and upregulate anti-inflammatory IL-10 in central nervous system tissues. This has drawn interest in models of chronic stress, traumatic brain injury, and neuropathic pain.

 

4. NEUROTRANSMITTER REGULATION

Investigations using microdialysis and tissue homogenates have demonstrated that N-Acetyle Selank Amidate  may alter extracellular levels of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in the prefrontal cortex and hippocampus. These changes are region-specific and dose-dependent, offering a research avenue for understanding its mechanism of action.

 

5. VIRAL & IMMUNE RESEARCH (IN VITRO)

Due to its tuftsin homology, N-Acetyle Selank Amidate has been evaluated for its ability to modulate interferon-gamma (IFN-γ) and other antiviral signaling molecules in cultured immune cells. This application remains exploratory but is documented in peer-reviewed immunology literature.

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N- ACETYLE SEMAX AMIDATE RESEARCH PEPTIDE

PREMIUM SYNTHETIC HEPTAPEPTIDE FOR ADVANCED NEUROLOGICAL, COGNITIVE, AND NEUROPROTECTIVE RESEARCH

 

N- Acetyle Semax Amidate Research Peptide is a highly purified, synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) with the sequence identical to a fragment of adrenocorticotropic hormone (ACTH). Originally developed in Russia, Semax has become a cornerstone compound in preclinical neurological research due to its multifaceted effects on cognitive function, neuroprotection, and brain-derived neurotrophic factor (BDNF) expression.

 

N-Acetyl Semax Amidate (NA Semax) is a modified version of Semax, a nootropic peptide originally developed in Russia. The addition of N-terminal acetylation and C-terminal amidation makes the molecule more resistant to enzymatic breakdown, potentially increasing stability and duration of action compared with standard Semax.

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RESEARCH FOCUS: THE MULTIFACETED NEUROLOGICAL APPLICATIONS OF SEMAX

 

N- Acetyle Semax Amidate represents a unique class of research peptides with demonstrated effects across multiple neurological pathways. Its research applications span several critical areas of modern neuroscience:

• Cognitive Enhancement & Memory Formation:Investigating mechanisms of learning, memory consolidation, and information processing.
• Neuroprotection & Ischemic Injury:Studying cellular survival pathways during stroke models and other forms of neuronal damage.
• Neurotrophic Factor Modulation:Researching the regulation of Brain-Derived Neurotrophic Factor (BDNF) and its role in synaptic plasticity.
• Stress Response & Adaptation:Exploring the interplay between the peptide and the hypothalamic-pituitary-adrenal (HPA) axis.
• Ophthalmic Research:Examining potential neuroprotective effects in models of optic nerve damage and retinal degeneration.

 

 

1. SEMAX AS A COGNITIVE ENHANCER AND MEMORY MODULATOR

Mechanism of Action:
Semax exerts its potent nootropic-like effects through several interconnected mechanisms that are of high interest to neuroscience researchers:

• BDNF Upregulation:Semax significantly increases the expression of Brain-Derived Neurotrophic Factor (BDNF), a critical protein for neuronal survival, differentiation, and synaptic plasticity. This is considered one of its primary mechanisms of action.
• Neurotransmitter System Influence:It modulates the brain’s dopaminergic, serotonergic, and GABAergic systems, potentially improving attention, motivation, and stress resilience without causing sedation or hyperactivity.
• Enhanced Brain Energy Metabolism:Research suggests Semax can improve glucose utilization in the brain, supporting the high energy demands of active neurons.
• Activation of Neuroprotective Genes:It influences the expression of genes involved in cell survival and antioxidant defense.

 

 

Research Applications & Key Studies:

 

• Enhancement of Learning and Memory:Studies in rodent models have demonstrated that Semax administration can significantly improve performance in various learning and memory tasks, such as passive avoidance and Morris water maze.
• Study:Nootropic and anxiolytic activity of Semax in rodents
• Improvement of Cognitive Function Under Stress:Research indicates that Semax may help maintain cognitive performance under conditions of stress or fatigue, making it relevant for studies on cognitive resilience.
• Study:Effects of Semax on learning and memory in rats with different levels of anxiety

 

 

Best for: Investigating mechanisms of learning and memory, studying BDNF’s role in cognition, and developing interventions for cognitive enhancement.

 

2. SEMAX AS A NEUROPROTECTIVE AGENT

Mechanism of Action:
The neuroprotective properties of Semax are a major area of scientific interest, particularly in models of acute brain injury:

• Reduction of Excitotoxicity:It helps protect neurons from damage caused by excessive glutamate, a primary mechanism of cell death in stroke and trauma.
• Antioxidant Effects:Semax reduces oxidative stress by enhancing the activity of endogenous antioxidant systems in the brain.
• Anti-Apoptotic Action:It inhibits pathways that lead to programmed cell death (apoptosis), promoting neuronal survival.
• Improved Cerebral Blood Flow:Studies suggest it can enhance blood circulation in the brain, which is crucial for recovery after ischemic events.

 

Research Applications & Key Studies:

• Stroke and Cerebral Ischemia:Semax has shown significant promise in reducing infarct volume and improving functional outcomes in animal models of ischemic stroke.
• Study:Neuroprotective effects of Semax in a rat model of transient focal cerebral ischemia
• subcutaneously, starting immediately or shortly after the induction of ischemia.
• Traumatic Brain Injury (TBI):Research indicates that Semax can mitigate damage and improve recovery in models of TBI.
• Study:Effects of Semax on the recovery of sensorimotor function after traumatic brain injury in rats

 

Best for: Research on ischemic stroke, traumatic brain injury, neurodegenerative models, and general mechanisms of neuronal survival.

 

3. SEMAX IN OPHTHALMIC AND RETINAL RESEARCH

Mechanism of Action:
The retina is an extension of the central nervous system, and Semax’s neuroprotective effects extend to ocular structures:

• Retinal Ganglion Cell Protection:It may protect retinal ganglion cells from apoptosis in models of glaucoma and optic nerve damage.
• Anti-Inflammatory Action in the Eye:Reduces inflammation associated with retinal ischemia or neurodegenerative eye diseases.
• Support of Visual Pathway Function:Research suggests it may help preserve function in the entire visual pathway from the retina to the visual cortex.

 

Research Applications & Key Studies:

• Optic Nerve Damage:Studies have investigated the efficacy of Semax in preserving retinal function and structure after optic nerve crush or transection.
• Study:Neuroprotective effect of Semax in the model of optic nerve injury in rats
• Retinal Ischemia:Its effects on improving outcomes after retinal ischemic events have been documented in preclinical models.
• Study:Effects of Semax on the recovery of the retina after ischemia

 

Suggested Research Protocols for Ophthalmic Studies:

• Optic nerve injury models
• Retinal degeneration models

 

Best for: Investigating neuroprotection in glaucoma models, retinal ischemia, optic neuritis, and other neurodegenerative eye conditions.

 

4. MECHANISMS OF STRESS RESILIENCE AND EMOTIONAL REGULATION

Mechanism of Action:
Unlike traditional ACTH, Semax does not stimulate corticosteroid production but appears to modulate the stress response in a more adaptive manner:

• HPA Axis Modulation:It influences the hypothalamic-pituitary-adrenal axis, potentially promoting a more balanced stress response without leading to adrenal exhaustion.
• Anxiolytic-Like Effects:Demonstrates anxiety-reducing properties in animal models without the sedative side effects associated with many anxiolytic drugs.
• Emotional Behavior Influence:Research suggests it can affect behaviors related to depression and anxiety in a positive way.

 

Research Applications & Key Studies:

• Anxiolytic and Antidepressant-Like Effects:Studies in rodents have shown that Semax can reduce anxiety-like behaviors in tests such as the elevated plus maze and open field test.
• Study:Anxiolytic activity of Semax and its fragments (Same as above, covers multiple effects)
• Stress-Induced Cognitive Deficits:It has been shown to prevent or reduce learning and memory impairments caused by various stressors.

 

Best for: Research on stress physiology, anxiety and depression models, HPA axis function, and emotional behavior.

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EXPERIMENTAL PREPARATION

For accurate research application:

1. Reconstitutewith appropriate volume of bacteriostatic water
2. Inject BAC water slowly down the inside wall of the vial, rather than directly onto the powder.
3. Gently swirluntil fully dissolved (do not vortex)
4. Administerimmediately or store at 4°C protected from light
5. Reconstituted: Stable 30 days at 4°C

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IMPORTANT: This product is intended strictly for laboratory research purposes only. NOT for human or animal consumption. NOT for medical or diagnostic use. These products have not undergone evaluation by the U.S. Food and Drug Administration. By purchasing, you confirm compliance with all applicable regulations.